Famously, Acrobat itself has a problem with them, so those people who like to use Acrobat as a text editor (DON'T DO THIS) find that they can only see a few of the fourteen styles (This is an issue with ANY TTC font on a Mac that has more than 4 styles). Microsoft apps were an example of that, but have since been updated to properly list TTC fonts. For instance because the TTC file for Hevetica contains FOURTEEN styles, it doesn't work well with apps that are used to old font 'family' of' the typical four styles (Regular, Italic, Bold, Bold Italic). There are still many problems with the TTC version with certain apps, even on a Mac. If you're using a Mac, and have Helvetica Neue, yes, you are good to go FOR NOW but really, it's time to move on to OTF or choose a new typeface.
